Meta: Today’s entry begins as a diary’s; recanting previous efforts, describing occupying thoughts and intentions, as sitting on this higher perch with the hope of gaining a more accurate perspective of these written fields. Why not begin where yesterday ended. I had been in the process of exploring the sensation of a mental switch whose activation I’ve come to associate with a...
Meta: The first thing I’d like to note today is that yesterday’s meta-worries were both baseless and valuable. They demonstrated both these properties (virtues?) and in doing so characterised what is perhaps most valuable about this diary-style writing, namely, “try-it-and-see” and “learn-from-experience”. Yesterday’s example is perhaps in itself not...
Journal: Reading science literature: I did a once-over browse of the TRENDS journals that have been published so far in this month, and have selected a few that I thought could be interesting. In TRENDS IMMUNOL I found an article that claims to review what’s known about the genetic implications for mechanisms of IBS. This is not something I’ll read now, but appears to be a reference...
Editorial notes: This is the first of 51 Evernote entries titled according to the date on which they were written, making this a personal, chronological journal of observations, lessons learned and conclusions, together with an element of diary writing. Synopsis: Today I discover a foreign news service, muse about its benefits, get side-tracked onto developing an open mind. And then finally added...
Source: [TREND_G] The desired outcome after having ‘known‘ this concept is a novel perception. The seed for this perception is the concept of bioproxies, that I can define as ‘xyz’, and in the literature includes the following distinctions ‘a,b,c’. Example: Madagascar which was settled in the mid-first millennium: The local language is Malagasy which is...
Editorial notes: This is one of a number of entries found in Shai’s Evernote archives where he discusses his own methodology for researching and acquiring knowledge, and his preferred methods for storing his notes, taken during that process. Shai devises a system of four tiers of acquiring knowledge. He refers to them as Tier1 to Tier 4. The notes arising from this process of knowledge...
Concept: De-extinction Source: A Policy Forum piece in Science (April 5, 2013), titled: “What If Extinction Is Not Forever?“ Technology: Three approaches. Back-breeding is possible where genetic variants homologous to extinct species exist in surviving species. Cloning, as by using somatic cell nuclear transfer from an extinct subspecies (i.e. with other extant subspecies). Genetic...
Background: GPCRs known to signal from surface and to be internalized. Fact: Prove that GPCRs signal from endosomes. Interest: Adds complexity to particulars (ie. location) of GPCR signalling. Source: Research Highlights in Nat Rev MCB (May 2013) on Nature article (2013). Fact: RNA polymerase II (Pol II) transcription kinetics are modulated by signalling pathways that affect the rate of...
There is a Research Highlights piece (in Nat Rev Gen [Nature Review Genetics]) on a paper entitled Parallel evolutionary dynamics of adaptive diversification in Escherichia coli (in PLoS Biol), which studies the principle of sympatric diversification, which is the “organismal diversification or speciation that occurs without […] geographical separation of [the] diverging...
Source: Original research Letter in Nature (April 11, 2013). Background: Although it has been known that Northern latitudes have had extreme temperature highs, it is difficult to prove that those are higher than any in the past. Methods: Use hierarchical Bayesian approach…(?) Results: Recent years have the highest extremes, and approx. 0 lowest extremes. The past 20yrs are 1.16C higher than...
