Background: GPCRs known to signal from surface and to be internalized.
Fact: Prove that GPCRs signal from endosomes.
Interest: Adds complexity to particulars (ie. location) of GPCR signalling.
Source: Research Highlights in Nat Rev MCB (May 2013) on Nature article (2013).
Fact: RNA polymerase II (Pol II) transcription kinetics are modulated by signalling pathways that affect the rate of initiation or rate of residence at pause sites (i.e. where Pol II “waits” before continuing).
Interest: Adds a domain of regulation complexity to protein production.
Source: Research Highlights in Nat Rev MCB (May 2013) on an original research piece in Molecular Cell (April 25, 2013).
Background: SHC binds RTKs to activate pathway to ERK.
Fact: In the absence of RTK stimulation, SHC via its PTB (phosphotyrosine binding) domain binds ERK to inhibit ERK phosphorylation.
Interest: Adds complexity to the ERK pathway.
Source: Nat Rev MCB (May 2013).
