Editorial notes: In November 2010, Shai begins the second phase of his intellectual journey with an essay dedicated to scientific summation. Throughout 2010 Shai’s writings are focused primarily on book reviews with the occasional venture into reviews of science. This focus shifts in 2013 when Shai produces 24 science-related compilations. Between November 2010 and June 2016, Shai produces 60...
This is a summary of a review-piece published in the prestigious science journal Trends in Pharmacological Sciences in 2010 ([link]) entitled “Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis“. The publication was authored by Yann Mineur and Marina Picciotto and discussed the connection between smoking, nicotinic receptors, and depression. Below I...
LINE-1 retrotransposons are sections of DNA which are capable of copying themselves into another part of the genome. Although traditionally considered to merely epitomize the concept of the selfish gene, more recently they have been suggested to have physiological functions. Here I discuss the incredibly fascinating hypothesis that LINE-1 retrotransposons may be important in generating neuronal...
In a nutshell, the Antikythera Mechanism is the thing that should not be. It is a mechanical artifact discovered around a hundred years ago at the bottom of the ocean, dated to about a hundred years before the common era, and which uses gears and other impossibilities to predict astronomical phenomenon and align calendars. Its level of sophistication wouldn’t be approached until the...
The Origin of Speech is the title of an article published in Scientific American in 1960 by Charles F. Hockett. It is often cited, even today, for its suggestion that there are 13 “design-features” shared by all languages. The 13 design-features of language: Vocal-auditory channel – While it is true that we have cultural adaptations that don’t require vocalizing communication – sign...
This is not an introduction to chemistry or even to atomic theories. It’s an introduction to what atoms are with the aim of providing enough background to be useful for understanding molecular biology. Introduction “Nothing exists except atoms and empty space; everything else is opinion.” (Democritus c. 400 BCE) Atoms are the building blocks of the world. There are different...
The central dogma of biology says that DNA encodes RNA which encodes proteins In the beginning, you were a single cell made up from a fused sperm and egg. This cell had 23 pairs of chromosomes which together made up all your DNA – chromosomes are what DNA looks like when it’s tightly wrapped. DNA is a long code made up of four nucleotides that form a four-letter alphabet – ACGT...
Many drugs, and most drugs that are directed at cognitive processes (e.g. anti-depressants, hallucinogenics) target receptors. Receptors are proteins involved in the way cells in the body signal to each other. The following is a review of one particular type of receptor called the 5-HT2A receptor, and it’s role in mediating the effects of LSD. What is a receptor? Our body is made up of...
Editorial notes: This scientific analysis was found as a ‘draft’ entry in Everything2. It was last updated on 03/05/2011. In 2006 Harvard presented a short movie they’d contracted called The Inner Life of a Cell. This eight and a half minute production was a 3D animation of (ostensibly) what a cell could look like on an atomic level*. This forms the final chapter of my three...
Editorial notes: This Essay was found as a ‘draft’ entry in Everything2. It was last updated on 03/05/2011. To me, molecular biology is that part of biology that is concerned with the molecules that make up biological systems. It is concerned with those molecules’ lives, and the way they interact with each other. It manipulates molecules to test hypotheses. Although it may look...
