{"id":2523,"date":"2013-10-10T01:30:28","date_gmt":"2013-10-10T01:30:28","guid":{"rendered":"http:\/\/thetravellerslastjourney.com\/shai\/?p=2523"},"modified":"2019-07-21T12:42:52","modified_gmt":"2019-07-21T12:42:52","slug":"science-review-cancer-immunoscore-and-neurochronoarchitecture","status":"publish","type":"post","link":"https:\/\/thetravellerslastjourney.com\/shai\/2013\/10\/10\/science-review-cancer-immunoscore-and-neurochronoarchitecture\/","title":{"rendered":"Science Review: Cancer immunoscore and Neurochronoarchitecture"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong>Concept<\/strong>: Cancer immunoscore. Also: TNM staging.<br \/>\n<strong>Background<\/strong>: Cancers are\u00a0traditionally\u00a0scored using TNM (tumor, lymph node, metastasis) staging. Evidence that proximity of immune cells to\u00a0tumor\u00a0is correlative to therapy success.<br \/>\n<strong>Technology<\/strong>: Cancers can be beneficially scored by using description of local immune cells.<br \/>\n<strong>Source<\/strong>: Based on a News\u00a0piece published in Nature\u00a0(3 April 2013).<\/p>\n<p style=\"text-align: justify;\"><strong>Concept<\/strong>: Neurochronoarchitecture.<br \/>\n<strong>New idea<\/strong>: The brain&#8217;s chronoarchitecture refers to the\u00a0timeline of happenings across the brain as seen from the neurons&#8217; perspective. Different neuronal components (neurons, areas, etc) receive information from different components at different (external) time, resulting in different temporal hierarchies (internal timelines).<br \/>\n<strong>Source<\/strong>: A Spotlight\u00a0article in Trends in Cognitive Science\u00a0(February 2013).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Concept: Cancer immunoscore. Also: TNM staging. Background: Cancers are\u00a0traditionally\u00a0scored using TNM (tumor, lymph node, metastasis) staging. Evidence that proximity of immune cells to\u00a0tumor\u00a0is correlative to therapy success. Technology: Cancers can be beneficially scored by using description of local immune cells. Source: Based on a News\u00a0piece published in Nature\u00a0(3 April 2013). Concept: Neurochronoarchitecture. New idea: The [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[159,242,16,17],"tags":[],"metadata":[],"class_list":["post-2523","post","type-post","status-publish","format-standard","hentry","category-all-posts","category-evernote-entries","category-science","category-science-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":2438,"url":"https:\/\/thetravellerslastjourney.com\/shai\/2013\/04\/22\/time-and-the-brain-2\/","url_meta":{"origin":2523,"position":0},"title":"Time and the brain","author":"Pala","date":"April 22, 2013","format":false,"excerpt":"A Spotlight article[I] that considers the concept of the brain's chronoarchitecture; the timeline of happenings across the brain as seen from the neurons' perspective. Different neuronal components (neurons, areas, etc) hear about (get information from) different components at a different (external) time, resulting in different temporal hierarchies. [I]\u00a0The full title\u2026","rel":"","context":"In &quot;All Posts&quot;","block_context":{"text":"All Posts","link":"https:\/\/thetravellerslastjourney.com\/shai\/all-posts\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1717,"url":"https:\/\/thetravellerslastjourney.com\/shai\/2010\/11\/24\/line-1-retrotransposition-in-neurons-2\/","url_meta":{"origin":2523,"position":1},"title":"LINE-1 retrotransposition in neurons","author":"Pala","date":"November 24, 2010","format":false,"excerpt":"LINE-1\u00a0retrotransposons are sections of\u00a0DNA\u00a0which are capable of copying themselves into another part of the\u00a0genome. Although traditionally considered to merely epitomize the concept of the\u00a0selfish gene, more recently they have been suggested to have physiological functions. Here I discuss the\u00a0incredibly fascinating hypothesis\u00a0that\u00a0LINE-1\u00a0retrotransposons may be important in generating\u00a0neuronal variation. Selfish genes and\u2026","rel":"","context":"In &quot;All Posts&quot;","block_context":{"text":"All Posts","link":"https:\/\/thetravellerslastjourney.com\/shai\/all-posts\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1675,"url":"https:\/\/thetravellerslastjourney.com\/shai\/2011\/05\/03\/5-ht2a-receptor-2\/","url_meta":{"origin":2523,"position":2},"title":"5-HT2A receptor","author":"Pala","date":"May 3, 2011","format":false,"excerpt":"Many drugs, and most drugs that are directed at cognitive processes (e.g. anti-depressants, hallucinogenics) target\u00a0receptors. Receptors are\u00a0proteins involved in the way\u00a0cells\u00a0in the body signal to each other. The following is a review of one particular type of receptor called the 5-HT2A\u00a0receptor, and it's role in mediating the effects of\u00a0LSD. What\u2026","rel":"","context":"In &quot;All Posts&quot;","block_context":{"text":"All Posts","link":"https:\/\/thetravellerslastjourney.com\/shai\/all-posts\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":40,"url":"https:\/\/thetravellerslastjourney.com\/shai\/2014\/09\/28\/science-news-on-one-foot-circa-september-25\/","url_meta":{"origin":2523,"position":3},"title":"Science News on One Foot (circa September 25)","author":"Pala","date":"September 28, 2014","format":false,"excerpt":"Three headlines selected from this week's Science\/Nature journals: (1) Memory in the innate immune system, (2) water in extrasolar atmospheres, and (3) enhancing photosynthesis in crops. Herein I summarize these, highlighting what makes them interesting to this person.","rel":"","context":"In &quot;All Posts&quot;","block_context":{"text":"All Posts","link":"https:\/\/thetravellerslastjourney.com\/shai\/all-posts\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2444,"url":"https:\/\/thetravellerslastjourney.com\/shai\/2013\/04\/22\/whiskey-and-speed-in-aldinga\/","url_meta":{"origin":2523,"position":4},"title":"Science Review: Technology Briefs","author":"Pala","date":"April 22, 2013","format":false,"excerpt":"2012_11: Genomic Epidemiology\u00a0uses full genome sequencing of pathogens collected from (suspected) patients to trace the transmission vector. [http:\/\/www.sciencemag.org\/content\/338\/6110\/1019.summary] 2012_11: Biochar\u00a0is charred (heated without air) biomass, that has the potential to mitigate climate change and - important for its economic viability - benefit agriculture. For the former it removes carbon from\u2026","rel":"","context":"In &quot;All Posts&quot;","block_context":{"text":"All Posts","link":"https:\/\/thetravellerslastjourney.com\/shai\/all-posts\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1712,"url":"https:\/\/thetravellerslastjourney.com\/shai\/2013\/05\/03\/the-prion-protein-as-a-receptor-for-amyloid-beta\/","url_meta":{"origin":2523,"position":5},"title":"The prion protein as a receptor for amyloid-beta","author":"Pala","date":"May 3, 2013","format":false,"excerpt":"I'm currently - 03\/05\/13 - in the process of updating this. I've added the section \"Update (May 2013)\", which is still a work in process (i.e. otherwise I would delete this note here). The title of this node comes from a\u00a0Nature\u00a0communication in which recent research linking the\u00a0prion protein (PrP)\u00a0and the\u00a0amyloid-beta\u2026","rel":"","context":"In &quot;All Posts&quot;","block_context":{"text":"All Posts","link":"https:\/\/thetravellerslastjourney.com\/shai\/all-posts\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/padotI-EH","_links":{"self":[{"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/posts\/2523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/comments?post=2523"}],"version-history":[{"count":0,"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/posts\/2523\/revisions"}],"wp:attachment":[{"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/media?parent=2523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/categories?post=2523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/tags?post=2523"},{"taxonomy":"metadata","embeddable":true,"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/metadata?post=2523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}