{"id":2484,"date":"2013-04-29T16:19:07","date_gmt":"2013-04-29T16:19:07","guid":{"rendered":"http:\/\/thetravellerslastjourney.com\/shai\/?p=2484"},"modified":"2019-07-14T02:36:52","modified_gmt":"2019-07-14T02:36:52","slug":"greenblatt-the-swerve","status":"publish","type":"post","link":"https:\/\/thetravellerslastjourney.com\/shai\/2013\/04\/29\/greenblatt-the-swerve\/","title":{"rendered":"Science Review: Molecular biology facts"},"content":{"rendered":"

Background<\/strong>: GPCRs known to signal from surface and to be internalized.
\nFact<\/strong>: Prove that GPCRs signal from endosomes.
\nInterest<\/strong>: Adds complexity to particulars (ie. location) of GPCR signalling.
\nSource<\/strong>: Research Highlights in Nat Rev<\/a><\/em> MCB\u00a0(May 2013) on Nature\u00a0article (2013).<\/p>\n

Fact<\/strong>: RNA polymerase II (Pol II) transcription kinetics are modulated by signalling pathways that affect the rate of initiation or rate of residence at pause sites (i.e. where Pol II “waits” before continuing).
\nInterest<\/strong>: Adds a domain of regulation complexity to protein production.
\nSource<\/strong>: Research Highlights in Nat Rev MCB\u00a0(May 2013) on an original research piece in\u00a0Molecular Cell\u00a0(April 25, 2013).<\/p>\n

Background<\/strong>: SHC binds RTKs to activate pathway to ERK.
\nFact<\/strong>: In the absence of RTK stimulation, SHC via its PTB (phosphotyrosine binding) domain binds ERK to inhibit ERK phosphorylation.
\nInterest<\/strong>: Adds complexity to the ERK pathway.
\nSource<\/strong>: Nat Rev MCB<\/a><\/em>\u00a0(May 2013).<\/p>\n","protected":false},"excerpt":{"rendered":"

Background: GPCRs known to signal from surface and to be internalized. Fact: Prove that GPCRs signal from endosomes. Interest: Adds complexity to particulars (ie. location) of GPCR signalling. Source: Research Highlights in Nat Rev MCB\u00a0(May 2013) on Nature\u00a0article (2013). Fact: RNA polymerase II (Pol II) transcription kinetics are modulated by signalling pathways that affect the […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[159,206,242,16,17],"tags":[],"metadata":[],"class_list":["post-2484","post","type-post","status-publish","format-standard","hentry","category-all-posts","category-biology","category-evernote-entries","category-science","category-science-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":159,"url":"https:\/\/thetravellerslastjourney.com\/shai\/2013\/08\/18\/science-090813-ii-pubpeer-social-influence-bias-transcription-factories-microbiome-speciation-and-neuronal-methylation\/","url_meta":{"origin":2484,"position":0},"title":"Science 090813 II: PubPeer, social influence bias, transcription factories, microbiome speciation, and neuronal methylation","author":"Pala","date":"August 18, 2013","format":false,"excerpt":"This is a continuation of an effort to review\u00a0Science 9 August 2013 Vol. 341 no. 6416. V. PubPeer is a nice, interesting, and new website, designed to allow readers to critique papers they've read. VI. P647, I read the full research paper, entitled Social Influence Bias: A Randomized Experiment\u00a0- basically\u2026","rel":"","context":"In "All Posts"","block_context":{"text":"All Posts","link":"https:\/\/thetravellerslastjourney.com\/shai\/all-posts\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2621,"url":"https:\/\/thetravellerslastjourney.com\/shai\/2013\/10\/14\/science-review-nature-journal-reading\/","url_meta":{"origin":2484,"position":1},"title":"Monday October 14, 2013","author":"Pala","date":"October 14, 2013","format":false,"excerpt":"This is Nature October 10 2013, Vol. 502, Iss. 7470, Pp. 141-264. Big weapons have little downside. Secrets of trial data revealed. Earth science: The timing of climate change. Quantum physics: Watching the wavefunction collapse - - I'm not reviewing this article (but bookmarked) because I simply do not have\u2026","rel":"","context":"In "All Posts"","block_context":{"text":"All Posts","link":"https:\/\/thetravellerslastjourney.com\/shai\/all-posts\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1076,"url":"https:\/\/thetravellerslastjourney.com\/shai\/2016\/08\/08\/musings-on-acetic-acid\/","url_meta":{"origin":2484,"position":2},"title":"Musings on Acetic Acid","author":"Pala","date":"August 8, 2016","format":false,"excerpt":"An original introduction to the science and nutrition of apple cider vinegar (ACV) supplementation for horses Or; fact versus fantasy ACV is a popular supplement given to horses (as well as cattle and people), and has been claimed to do everything from curing cancer to osteoporosis, to repelling mosquitos. This\u2026","rel":"","context":"In "All Posts"","block_context":{"text":"All Posts","link":"https:\/\/thetravellerslastjourney.com\/shai\/all-posts\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2510,"url":"https:\/\/thetravellerslastjourney.com\/shai\/2013\/04\/29\/parallel-evolutionary-dynamics-of-adaptive-diversification\/","url_meta":{"origin":2484,"position":3},"title":"Science Review: Parallel evolutionary dynamics of adaptive diversification","author":"Pala","date":"April 29, 2013","format":false,"excerpt":"There is a Research Highlights piece (in Nat Rev Gen [Nature Review Genetics]) on a paper entitled Parallel evolutionary dynamics of adaptive diversification in Escherichia coli (in PLoS Biol), which studies the principle of\u00a0sympatric diversification, which is the \"organismal diversification or speciation that occurs without [...] geographical separation of [the]\u2026","rel":"","context":"In "All Posts"","block_context":{"text":"All Posts","link":"https:\/\/thetravellerslastjourney.com\/shai\/all-posts\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2564,"url":"https:\/\/thetravellerslastjourney.com\/shai\/2013\/10\/10\/science-review-a-jump-start-for-electroceuticals\/","url_meta":{"origin":2484,"position":4},"title":"Science Review: A jump-start for electroceuticals","author":"Pala","date":"October 10, 2013","format":false,"excerpt":"Technology: Electroceuticals are made conceivable by\u00a0recent advances, including optogenetics, microsurgery, nanotechnology-based energy production. Future research needed in\u00a0\u00a0Finer neural circuits, including their anatomy and\u00a0signalling\u00a0patterns vs response. Source:\u00a0\u00a0A\u00a0Comment\u00a0piece in\u00a0Nature\u00a0(April 11, 2013).","rel":"","context":"In "All Posts"","block_context":{"text":"All Posts","link":"https:\/\/thetravellerslastjourney.com\/shai\/all-posts\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2593,"url":"https:\/\/thetravellerslastjourney.com\/shai\/2013\/04\/10\/random-facts\/","url_meta":{"origin":2484,"position":5},"title":"Random Facts","author":"Pala","date":"April 10, 2013","format":false,"excerpt":"Fact: \"When humans cannot tell where the gaze is focused, they assume that people are looking at them.\" {Narcissistic gaze prediction}. Source: A\u00a0Research Highlight\u00a0in\u00a0Nature\u00a0(April 11, 2013) on original research in\u00a0Current Biology. Fact: Not all neurons follow neurotrophic theory, some die per pre-programming independent of environment. Source: Perspective in Science\u00a0(April 5,\u2026","rel":"","context":"In "All Posts"","block_context":{"text":"All Posts","link":"https:\/\/thetravellerslastjourney.com\/shai\/all-posts\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/padotI-E4","_links":{"self":[{"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/posts\/2484","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/comments?post=2484"}],"version-history":[{"count":0,"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/posts\/2484\/revisions"}],"wp:attachment":[{"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/media?parent=2484"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/categories?post=2484"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/tags?post=2484"},{"taxonomy":"metadata","embeddable":true,"href":"https:\/\/thetravellerslastjourney.com\/shai\/wp-json\/wp\/v2\/metadata?post=2484"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}